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- Title
Extracellular Vesicles of Bacteria Mediate Intercellular Communication: Practical Applications and Biosafety.
- Authors
Chernov, V. M.; Mouzykantov, A. A.; Baranova, N. B.; Chernova, O. A.
- Abstract
Extracellular vesicles secreted by bacterial cells are the focus of close attention of researchers. They are enriched with bioactive molecules, mediate the intercellular communication of micro- and macroorganisms, participate in the adaptation of bacteria to stressful conditions, reprogramming target cells, and modulating immunoreactivity in higher organisms, thus changing the structure of microbial communities and ecosystems. The unique properties of bacterial extracellular vesicles (BEVs) open broad prospects for their practical application, in clinical medicine, agriculture, biotechnology, and ecology as diagnostic markers, vaccines, new biological products, and means of their delivery. However, to implement practical applications a number of problems need to be solved. This review focuses on the ambiguous role of BEVs in the regulation of living systems, the problem of assessing the safety of BEVs and approaches to its solution related to innovative technologies.
- Subjects
EXTRACELLULAR vesicles; CELL communication; TECHNOLOGICAL innovations; BIOSAFETY; BACTERIAL cells; BACTERIA; ECOSYSTEMS; SOIL microbial ecology
- Publication
Applied Biochemistry & Microbiology, 2023, Vol 59, Issue 2, p99
- ISSN
0003-6838
- Publication type
Article
- DOI
10.1134/S0003683823020035