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- Title
Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions
- Authors
Headey, Stephen J.; Keizer, David W.; Yao, Shenggen; Wallace, John C.; Bach, Leon A.; Norton, Raymond S.
- Abstract
Insulin-like growth factors (IGFs) are important mediators of growth and IGF-binding proteins (IGFBPs) 1–6 regulate IGF actions. As IGFBP C-terminal domains contribute to high-affinity IGF binding, we have defined the binding site for the C-domain of IGFBP-6 on IGF-II using NMR. This site lies adjacent to and between the binding sites for the IGFBP N-domain and IGF-I receptor (IGFIR), which have previously been found on opposite sides of the IGF molecule. The C-domain is therefore likely to interfere with IGF binding to the IGFIR, providing a structural basis for the potent inhibitory effects of intact IGFBPs on IGF actions.
- Subjects
PROINSULIN; INSULIN structure; MAGNETIC resonance; IMMUNOSPECIFICITY
- Publication
FEBS Letters, 2004, Vol 568, Issue 1-3, p19
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2004.04.091