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- Title
Structural features of transmembrane helices
- Authors
Hildebrand, Peter Werner; Preissner, Robert; Frömmel, Cornelius
- Abstract
A total of 160 transmembrane helices of 15 non-homologous high-resolution X-ray protein structures have been analyzed in respect of their structural features. The dihedral angles and hydrogen bonds of the helical sections that span the hydrophobic interior of the lipid bilayer have been investigated. The Ramachandran plot of protein channels and solute transporters exhibit a significant shift Δ (φ- and ψ-angles) of Δ mean (+4.5° and −5.4°), compared to a reference group of 151 α-helices of the same average length derived from water-soluble globular proteins. At the C-termini of transmembrane helices structural motifs equivalent to the Gly-caps of helices in globular proteins have been found, with two third of the transmembrane Gly-caps taking up a primary structure that is typically not found at helix termini exposed to a polar solvent. The structural particularities reported here are relevant for the three-dimensional modelling of membrane protein structures.
- Subjects
MEMBRANE proteins; LIPIDS; HYDROGEN bonding; ION channels
- Publication
FEBS Letters, 2004, Vol 559, Issue 1-3, p145
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(04)00061-4