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- Title
Polyhalogenated benzo- and naphthoquinones are potent inhibitors of plant and bacterial ureases
- Authors
Ashiralieva, Ainura; Kleiner, Diethelm
- Abstract
Polyhalogenated benzo- and naphthoquinones were found to be potent inhibitors of pure ureases from Bacillus pasteurii and Canavalia ensiformis. They also inhibited ureases in whole cells of Helicobacter pylori, Klebsiella oxytoca and Proteus mirabilis. Inhibition was non-competitive with Ki values in the micromolar range or below. Inhibition was irreversible as shown by equilibrium dialysis. Inhibitory power decreased considerably when halogens were replaced by –OH, –CN, alkoxy or alkyl groups.
- Subjects
HALOCARBONS; QUINONE; UREASE; HELICOBACTER pylori
- Publication
FEBS Letters, 2003, Vol 555, Issue 2, p367
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)01289-4