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- Title
Microwave radiation can alter protein conformation without bulk heating
- Authors
de Pomerai, David I.; Smith, Brette; Dawe, Adam; North, Kate; Smith, Tim; Archer, David B.; Duce, Ian R.; Jones, Donald; Candido, E. Peter M.
- Abstract
Exposure to microwave radiation enhances the aggregation of bovine serum albumin in vitro in a time- and temperature-dependent manner. Microwave radiation also promotes amyloid fibril formation by bovine insulin at 60°C. These alterations in protein conformation are not accompanied by measurable temperature changes, consistent with estimates from field modelling of the specific absorbed radiation (15–20 mW kg−1). Limited denaturation of cellular proteins could explain our previous observation that modest heat-shock responses are induced by microwave exposure in Caenorhabditis elegans. We also show that heat-shock responses both to heat and microwaves are suppressed after RNA interference ablating heat-shock factor function.
- Subjects
BOVINE anatomy; ALBUMINS
- Publication
FEBS Letters, 2003, Vol 543, Issue 1-3, p93
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00413-7