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- Title
Antisense down regulation of NtBI-1 in tobacco BY-2 cells induces accelerated cell death upon carbon starvation
- Authors
Bolduc, Nathalie; Brisson, Louise F.
- Abstract
Bax inhibitor-1 (BI-1) protein is proposed to be a conserved programmed cell death suppressor. In this report, we investigate the anti-apoptotic function of plant BI-1 by antisense (AS) down regulation of NtBI-1 in Nicotiana tabacum cv. BY-2 cells. We observed that AS cell lines were more susceptible to autophagy, internucleosomal DNA fragmentation and death than control cells when subjected to sucrose starvation and hypo-osmotic shock, in agreement with a role of BI-1 as a death inhibitor.
- Subjects
CHEMICAL inhibitors; TOBACCO
- Publication
FEBS Letters, 2002, Vol 532, Issue 1/2, p111
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)03650-5