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- Title
PEG-Based Clotrimzole Microparticles Improved Ischemia-Reperfusion Injury in Rat Testicular Torsion and Detorsion Model: Evaluation of Tissue Oxidative Stress.
- Authors
Yariravesh, Pedram; Mohammadi, Rahim; Asri-Resaei, Siamak; Alizadeh, Arash
- Abstract
A rat testis model was used to assess effects of polyethylene glycol (PEG) clotrimazole microparticles on ischemia-reperfusion injury. Forty-eight healthy male Wistar rats were included and randomized into six investigational groups (n = 8): Group SHAM: Merely laparotomy was implemented. Group ISCHEMIA: Merely a 3-hour interval ischemia was done. Group I/R: A 3-hour interval ischemia, three-hour reperfusion for left testis, and one-week reperfusion for right testis were done and 20 µL normal saline was administered intraperitoneally (IP) 30 min before termination of ischemia. Group I/R/PEG: The same as group I/R as well as 20 µL PEG (IP) 30 min before termination of ischemia. Group I/R/CLTMZLMP: The same as group I/R and 20 µl (10 mg/kg) of clotrimazole microparticles (IP) 30 min before termination of ischemia. Group I/R/PEGCLTMZLMP: The same as group I/R and 20 µL PEG-based clotrimazole microparticles (IP) 30 min before termination of ischemia. Evaluations were based on analyses of biochemical assays. PEG-based clotrimazole microparticles improved enhanced antioxidant activity (p < 0.05). PEG-based clotrimazole microparticles could be helpful in minimizing ischemia-reperfusion injury in testicular tissue exposed to ischemia
- Subjects
POLYETHYLENE glycol; ISCHEMIA; SPERMATIC cord torsion; OXIDATIVE stress; ABDOMINAL surgery
- Publication
Iranian Journal of Veterinary Surgery, 2024, Vol 19, Issue 1, p1
- ISSN
2008-3033
- Publication type
Article
- DOI
10.30500/ivsa.2023.398707.1351