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- Title
Carcinoma of the Ampulla of Vater: Expression of Cancer- Associated Antigens Inversely Correlated with Prognosis.
- Authors
Kamisawa, Terumi; Fukayama, Masashi; Koike, Morio; Tabata, Ikuo; Egawa, Naoto; Isawa, Tomoaki; Okamoto, Atsutake; Hayashi, Yukiko
- Abstract
To obtain some useful pathologic indicators for predicting the prognosis in carcinomas of the ampulla of Vater, we analyzed 24 surgically resected ampullary carcinomas pathologically with immunohistochemistry of cancer-associated antigens. Pancreatic invasion, lymph node metastasis, and histology of the tumor were significantly correlated with poor prognosis (<em>p</em> < 0.01), but the size or ulceration of the tumor did not significantly affect the prognosis (<em>p</em> < 0.05). Immunohistochemically, diffuse positivity for anti-CA19-9 monoclonal antibody was demonstrated in 10 carcinomas and that for anti-carcinoembryonic antigen (CEA), in 10. Eight of them showed synchronously diffuse immuno-reactivities for both antigens. Although there was no significant correlation between diffuse positivity for CA19-9 and pathologic factors, CA19-9-positive cases exhibited significantly poor prognoses (<em>p</em> < 0.01). Diffuse positivity for CEA was correlated with pancreatic invasion (<em>p</em> < 0.05) and poor prognosis (<em>p</em> < 0.05). Immunohistochemical study of cancer-associated antigens may disclose some malignant potential of ampullary carcinoma other than that expressed in the morphology. Furthermore, because of the consistency of staining results, immunohistochemistry of cancer-associated antigens may also be useful in predicting preoperatively the prognosis of ampullary carcinoma in biopsied materials.
- Subjects
AMPULLA of Vater cancer; BILE ducts; PANCREATIC duct; IMMUNOHISTOCHEMISTRY; ANTIGENS; PANCREAS; LYMPH node cancer; METASTASIS; HISTOLOGY; MONOCLONAL antibodies
- Publication
American Journal of Gastroenterology (Springer Nature), 1988, Vol 83, Issue 10, p1118
- ISSN
0002-9270
- Publication type
Article