We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning.
- Authors
Balschun, Detlef; Wolfer, David P.; Bertocchini, Federica; Barone, Virginia; Conti, Antonio; Zuschratter, Werner; Missiaen, Ludwig; Lipp, Hans-Peter; Frey, J. Uwe; Sorrentino, Vincenzo
- Abstract
Deletion of the ryanodine receptor type 3 (RyR3) results in specific changes in hippocampal synaptic plasticity, without affecting hippocampal morphology, basal synaptic transmission or presynaptic function. Robust long-term potentiation (LTP) induced by repeated, strong tetanization in the CA1 region and in the dentate gyrus was unaltered in hippocampal slices in vitro, whereas weak forms of plasticity generated by either a single weak tetanization or depotentiation of a robust LTP were impaired. These distinct physiological deficits were paralleled by a reduced flexibility in relearning a new target in the water-maze. In contrast, learning performance in the acquisition phase and during probe trial did not differ between the mutants and their wild-type littermates. In the open-field, RyR3-/- mice displayed a normal exploration and habituation, but had an increased speed of locomotion and a mild tendency to circular running. The observed physiological and behavioral effects implicate RyR3-mediated Ca2+ release in the intracellular processes underlying spatial learning and hippocampal synaptic plasticity.
- Subjects
RYANODINE; CELL receptors; NEUROPLASTICITY; SPATIAL behavior; CALCIUM channels; NEURAL transmission
- Publication
EMBO Journal, 1999, Vol 18, Issue 19, p5264
- ISSN
0261-4189
- Publication type
Article
- DOI
10.1093/emboj/18.19.5264