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- Title
Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI.
- Authors
Zhao, Jianhua; Bradfield, Jonathan P.; Zhang, Haitao; Annaiah, Kiran; Wang, Kai; Kim, Cecilia E.; Glessner, Joseph T.; Frackelton, Edward C.; Otieno, F. George; Doran, James; Thomas, Kelly A.; Garris, Maria; Hou, Cuiping; Chiavacci, Rosetta M.; Li, Mingyao; Berkowitz, Robert I.; Hakonarson, Hakon; Grant, Struan F.A.
- Abstract
OBJECTIVE--A number of studies have found that BMI in early life influences the risk of developing type 2 diabetes later in life. Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood. RESEARCH DESIGN AND METHODS--Using data from an ongoing GWAS of pediatric BMI in our cohort, we investigated the association of pediatric BMI with 20 single nucleotide polymorphisms at 18 type 2 diabetes loci uncovered through GWAS, consisting of ADAMTS9, CDC123-CAMKID, CDKAL1, CDKN2A/B, EXT2, FTO, HHEX-IDE, IGF2BP2, the intragenic region on 11p12, JAZF1, KCNQ1, LOC387761, MTNR1B, NOTCH2, SLC3OA8, TCF7L2, THADA, and TSPAN8-LGR5. We randomly partitioned our cohort exactly in half in order to have a discovery cohort (n = 3,592) and a replication cohort (n = 3,592). RESULTS--Our data show that the major type 2 diabetes risk-conferring G allele of rs7923837 at the HHEX-IDE locus was associated with higher pediatric BMI in both the discovery (P = 0.0013 and survived correction for 20 tests) and replication (P = 0.023) sets (combined P = 1.01 x 10[sup -4]). Association was not detected with any other known type 2 diabetes loci uncovered to date through GWAS except for the well-established FTO. CONCLUSIONS--Our data show that the same genetic HHEX-IDE variant, which is associated with type 2 diabetes from previous studies, also influences pediatric BMI. Diabetes 59: 751-755, 2010
- Subjects
TYPE 2 diabetes; NUCLEOTIDES; GENETIC polymorphisms; LOCUS (Genetics); BODY mass index
- Publication
Diabetes, 2010, Vol 59, Issue 3, p751
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db09-0972