We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Adding Carbohydrate to High-Fat Meal Blunts Postprandial Lipemia in Women and Reduces Bioavailability of Meal-Derived Fatty Acids in the Systemic Circulation.
- Authors
Knuth, Nicolas D.; Remias, David B.; Horowitz, Jeffrey F.
- Abstract
The lipemic response to a meal is an important disease risk factor. The purpose of this study was to determine the effect of adding carbohydrate to a fat meal on the bioavailability of ingested fat in different blood lipid fractions in men and women. On two separate occasions, 15 healthy adults (7 women, 8 men) ate: 1) a high-fat meal (0.7g fat/kg) [FAT], and 2) the same fat meal with added CHO (1g CHO/kg) [FAT+CHO] in the morning after a 12h fast. Both meals were supplemented with [sup 13]C-palmitate (25mg/kg). Plasma concentrations of TG, fatty acids, insulin, and glucose were measured in blood samples taken hourly from Oh to 8h after the meal. In addition, TG concentration in chylomicron (CHYLO-TG), and in very low density lipoprotein (VLDL-TG) fractions were measured after separation by density gradient centrifugation. [sup 13]C recovery in plasma lipid fractions was assessed using GC/MS. The addition of CHO to the fat meal increased plasma glucose and insulin concentrations identically in men and women. In contrast, adding CHO to the fat meal reduced the postprandial plasma TG concentration in the 4 hours after the meal in women (average 4h [TG]: 1.26±0.11 and 0.99±0.11 mM; P<0.05) but not in men (average 4h [TG]: 1.101±0.16 and 1.13±0.19 mM). CHYLO-TG paralleled these changes in total plasma TG concentration in both men and women. Similarly, adding CHO to the fat meal reduced VLDL-TG in women but not in men, indicating that CHO ingestion reduced the incorporation of fat into VLDL by the liver in women. Finally, the recovery of [sup 13]C-palmitate in plasma fatty acid fraction was lower after FAT+CHO compared with FAT in both men and women, suggesting that the addition of CHO to a fat meal resulted in a relatively rapid increase in the removal of meal-derived fat by peripheral tissues (e.g. adipose tissue and/or skeletal muscle). Overall, these data indicate that adding CHO to a fat meal markedly blunts the plasma TG response in women, and reduces the contribution of meal-derived fatty acids in the systemic circulation.
- Subjects
CARBOHYDRATE content of food; DIETARY fats; LIPEMIA; BLOOD lipids; BIOAVAILABILITY; INSULIN; BLOOD sugar
- Publication
Diabetes, 2007, Vol 56, pA368
- ISSN
0012-1797
- Publication type
Article