We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.
- Authors
Florez, Jose C.; Agapakis, Christina M.; Burtt, Noel P.; Sun, Maria; Almgren, Peter; Råstam, Lennart; Tuomi, Tiinamaija; Gaudet, Daniel; Hudson, Thomas J.; Daly, Mark J.; Ardlie, Kristin G.; Hirschhorn, Joel N.; Groop, Leif; Altshuler, David; Burtt, Noël P; Råstam, Lennart
- Abstract
Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated common sequence variants in PTPN1 with type 2 diabetes and diabetes-related phenotypes. We sought to replicate the association of common single nucleotide polymorphisms (SNPs) and haplotypes in PTPN1 with type 2 diabetes, fasting plasma glucose, and insulin sensitivity in a large collection of subjects. We assessed linkage disequilibrium, selected tag SNPs, and typed these markers in 3,347 cases of type 2 diabetes and 3,347 control subjects as well as 1,189 siblings discordant for type 2 diabetes. Despite power estimated at >95% to replicate the previously reported associations, no statistically significant evidence of association was observed between PTPN1 SNPs or common haplotypes with type 2 diabetes or with diabetic phenotypes.
- Subjects
PROTEIN-tyrosine phosphatase; GENES; TYPE 2 diabetes; INSULIN; CHROMOSOMES; PHENOTYPES; COMPARATIVE studies; DISEASE susceptibility; ESTERASES; GENE mapping; GENETIC polymorphisms; RESEARCH methodology; MEDICAL cooperation; NUCLEOTIDES; RESEARCH; EVALUATION research; CASE-control method; GENOTYPES
- Publication
Diabetes, 2005, Vol 54, Issue 6, p1884
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.54.6.1884