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- Title
Sodium Ferrous Citrate and 5-Aminolevulinic Acid Exert a Therapeutic Effect on Endotoxin-Induced Uveitis in Rats.
- Authors
Otaka, Yuya; Kanai, Kazutaka; Okada, Daiki; Nagai, Noriaki; Yamashita, Yohei; Ichikawa, Yoichiro; Tajima, Kazuki
- Abstract
The metabolism of 5-aminolevulinic acid (ALA) is more efficient when combined with sodium ferrous citrate (SFC). Our previous study revealed that oral administration of ALA, which has anti-inflammatory properties, and SFC (ALA/SFC) immediately before lipopolysaccharide (LPS) inoculation suppressed endotoxin-induced uveitis (EIU) in rats. However, the therapeutic effect of ALA/SFC post-administration remains unexplored. Hence, this study aimed to evaluate the therapeutic efficacy of ALA/SFC on EIU in rats, which were administered with a gastric gavage of ALA/SFC (100/157 mg/kg) or prednisolone (Pred, 10 mg/kg) after 4 h of LPS inoculation. The treatment groups showed ameliorated clinical scores, inflammatory cells, protein levels in the aqueous humor (AqH), and histopathologic evaluation 24 h after LPS inoculation. Furthermore, the treatment groups had reduced tumor necrosis factor-α, nitric oxide, prostaglandin E2, and interleukin-6 levels in the AqH. ALA/SFC demonstrated an anti-inflammatory effect equivalent to that demonstrated by Pred. These findings indicate that ALA/SFC exerts a therapeutic effect on EIU in rats, indicating its clinical usefulness in uveitis treatment.
- Subjects
TREATMENT effectiveness; UVEITIS; ORAL drug administration; AQUEOUS humor; CITRATES; LIPOPOLYSACCHARIDES
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 17, p13525
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241713525