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- Title
TNF-α and the Development of the Neonatal Immune System: Implications for Inhibitor Use in Pregnancy.
- Authors
Arsenescu, Razvan; Arsenescu, Violeta; de Villiers, Willem J. S.
- Abstract
Inflammatory bowel diseases, Crohn's disease, and ulcerative colitis have an unpredictable course during and after pregnancy (1). There is a great deal of interest in treating moderate to severe active inflammatory bowel disease with anti-tumor necrosis factor (anti-TNF) biologics in pregnant women (2). We lack definitive information about the effects of these agents on the development of the immune system of the human fetus and the newborn baby. Anti-TNF agents fall within US Food and Drug Administration's (FDA) category B regarding fetal risk, indicating that no adequate and well-controlled studies have been conducted in pregnant or nursing women. Here, we review animal studies (of both mice and nonhuman primates) that examine the role of TNF and its inhibitors in the normal development of the immune system.
- Subjects
UNITED States; TUMOR necrosis factors; NEWBORN infant immunology; CHEMICAL inhibitors; IMMUNOLOGICAL aspects of pregnancy; UNITED States. Food &; Drug Administration; LABORATORY mice; PRIMATES as laboratory animals
- Publication
American Journal of Gastroenterology (Springer Nature), 2011, Vol 106, Issue 4, p559
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1038/ajg.2011.5