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Emerging paradigms in GPCR allostery: implications for drug discovery.
Published in:
Nature Reviews Drug Discovery, 2013, v. 12, n. 8, p. 630, doi. 10.1038/nrd4052
By:
- Wootten, Denise;
- Christopoulos, Arthur;
- Sexton, Patrick M.
Publication type:
Article
The metabolic effects of mirabegron are mediated primarily by β<sub>3</sub>-adrenoceptors.
Published in:
Pharmacology Research & Perspectives, 2020, v. 8, n. 5, p. 1, doi. 10.1002/prp2.643
By:
- Dehvari, Nodi;
- Masaaki Sato;
- Bokhari, Muhammad Hamza;
- Kalinovich, Anastasia;
- Seungmin Ham;
- Jie Gao;
- Nguyen, Huong T. M.;
- Whiting, Lynda;
- Mukaida, Saori;
- Merlin, Jon;
- Ling Yeong Chia;
- Wootten, Denise;
- Summers, Roger J.;
- Evans, Bronwyn A.;
- Bengtsson, Tore;
- Hutchinson, Dana S.
Publication type:
Article
Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8069, doi. 10.3390/ijms23158069
By:
- Lu, Jessica;
- Piper, Sarah J.;
- Zhao, Peishen;
- Miller, Laurence J.;
- Wootten, Denise;
- Sexton, Patrick M.
Publication type:
Article
Thermo Scientific™ Glacios Cryo-TEM: A Versatile 200 kV Tool for Structure-Based Drug Discovery.
Published in:
2021
By:
- Drulyte, Ieva;
- Zhang, Xin;
- Johnson, Rachel;
- Koh, Adrian;
- Masiulis, Simonas;
- Unger, Sebastian;
- Pechnikova, Evgeniya;
- Wootten, Denise;
- Sexton, Patrick;
- Belousoff, Matthew
Publication type:
Abstract
Thermo Scientific™ Glacios Cryo-TEM: A Versatile 200 kV Tool for Structure-Based Drug Discovery.
Published in:
2021
By:
- Drulyte, Ieva;
- Zhang, Xin;
- Johnson, Rachel;
- Koh, Adrian;
- Masiulis, Simonas;
- Unger, Sebastian;
- Pechnikova, Evgeniya;
- Wootten, Denise;
- Sexton, Patrick;
- Belousoff, Matthew
Publication type:
Abstract
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27760-0
By:
- Deganutti, Giuseppe;
- Liang, Yi-Lynn;
- Zhang, Xin;
- Khoshouei, Maryam;
- Clydesdale, Lachlan;
- Belousoff, Matthew J.;
- Venugopal, Hari;
- Truong, Tin T.;
- Glukhova, Alisa;
- Keller, Andrew N.;
- Gregory, Karen J.;
- Leach, Katie;
- Christopoulos, Arthur;
- Danev, Radostin;
- Reynolds, Christopher A.;
- Zhao, Peishen;
- Sexton, Patrick M.;
- Wootten, Denise
Publication type:
Article
Routine sub-2.5 Å cryo-EM structure determination of GPCRs.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24650-3
By:
- Danev, Radostin;
- Belousoff, Matthew;
- Liang, Yi-Lynn;
- Zhang, Xin;
- Eisenstein, Fabian;
- Wootten, Denise;
- Sexton, Patrick M.
Publication type:
Article
Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions.
Published in:
Scientific Reports, 2016, p. 37744, doi. 10.1038/srep37744
By:
- Tsend-Ayush, Enkhjargal;
- He, Chuan;
- Myers, Mark A.;
- Andrikopoulos, Sof;
- Wong, Nicole;
- Sexton, Patrick M.;
- Wootten, Denise;
- Forbes, Briony E.;
- Grutzner, Frank
Publication type:
Article
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M<sub>4</sub> mAChR.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41199-5
By:
- Burger, Wessel A. C.;
- Pham, Vi;
- Vuckovic, Ziva;
- Powers, Alexander S.;
- Mobbs, Jesse I.;
- Laloudakis, Yianni;
- Glukhova, Alisa;
- Wootten, Denise;
- Tobin, Andrew B.;
- Sexton, Patrick M.;
- Paul, Steven M.;
- Felder, Christian C.;
- Danev, Radostin;
- Dror, Ron O.;
- Christopoulos, Arthur;
- Valant, Celine;
- Thal, David M.
Publication type:
Article
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Published in:
PLoS Biology, 2024, v. 22, n. 7, p. 1, doi. 10.1371/journal.pbio.3002673
By:
- Harikumar, Kaleeckal G.;
- Zhao, Peishen;
- Cary, Brian P.;
- Xu, Xiaomeng;
- Desai, Aditya J.;
- Dong, Maoqing;
- Mobbs, Jesse I.;
- Toufaily, Chirine;
- Furness, Sebastian G. B.;
- Christopoulos, Arthur;
- Belousoff, Matthew J.;
- Wootten, Denise;
- Sexton, Patrick M.;
- Miller, Laurence J.
Publication type:
Article
Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol.
Published in:
Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.789957
By:
- Harikumar, Kaleeckal G.;
- Coudrat, Thomas;
- Desai, Aditya J.;
- Dong, Maoqing;
- Dengler, Daniela G.;
- Furness, Sebastian G. B.;
- Christopoulos, Arthur;
- Wootten, Denise;
- Sergienko, Eduard A.;
- Sexton, Patrick M.;
- Miller, Laurence J.
Publication type:
Article
Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics.
Published in:
Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.684656
By:
- Miller, Laurence J.;
- Harikumar, Kaleeckal G.;
- Wootten, Denise;
- Sexton, Patrick M.
Publication type:
Article
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Published in:
PLoS Biology, 2021, v. 19, n. 6, p. 1, doi. 10.1371/journal.pbio.3001295
By:
- Mobbs, Jesse I.;
- Belousoff, Matthew J.;
- Harikumar, Kaleeckal G.;
- Piper, Sarah J.;
- Xu, Xiaomeng;
- Furness, Sebastian G. B.;
- Venugopal, Hari;
- Christopoulos, Arthur;
- Danev, Radostin;
- Wootten, Denise;
- Thal, David M.;
- Miller, Laurence J.;
- Sexton, Patrick M.
Publication type:
Article
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas.
Published in:
2019
By:
- Ostrovskaya, Anna;
- Hick, Caroline;
- Hutchinson, Dana S.;
- Stringer, Brett W.;
- Wookey, Peter J.;
- Wootten, Denise;
- Sexton, Patrick M.;
- Furness, Sebastian G. B.
Publication type:
journal article
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.83477
By:
- Vuckovic, Ziva;
- Jinan Wang;
- Vi Pham;
- Mobbs, Jesse I.;
- Belousoff, Matthew J.;
- Bhattarai, Apurba;
- Burger, Wessel A. C.;
- Thompson, Geoff;
- Yeasmin, Mahmuda;
- Nawaratne, Vindhya;
- Leach, Katie;
- van der Westhuizen, Emma T.;
- Khajehali, Elham;
- Yi-Lynn Liang;
- Glukhova, Alisa;
- Wootten, Denise;
- Lindsley, Craig W.;
- Tobin, Andrew;
- Sexton, Patrick;
- Danev, Radostin
Publication type:
Article
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35.
Published in:
2022
By:
- Qin, Cheng Xue;
- Norling, Lucy V.;
- Vecchio, Elizabeth A.;
- Brennan, Eoin P.;
- May, Lauren T.;
- Wootten, Denise;
- Godson, Catherine;
- Perretti, Mauro;
- Ritchie, Rebecca H.
Publication type:
journal article
The complexity of signalling mediated by the glucagon-like peptide-1 receptor.
Published in:
Biochemical Society Transactions, 2016, v. 44, n. 2, p. 582, doi. 10.1042/BST20150244
By:
- Fletcher, Madeleine M.;
- Halls, Michelle L.;
- Christopoulos, Arthur;
- Sexton, Patrick M.;
- Wootten, Denise
Publication type:
Article
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.
Published in:
Biochemical Society Transactions, 2013, v. 41, n. 1, p. 172, doi. 10.1042/BST20120236
By:
- Koole, Cassandra;
- Pabreja, Kavita;
- Savage, Emilia E.;
- Wootten, Denise;
- Furness, Sebastian G.B.;
- Miller, Laurence J.;
- Christopoulos, Arthur;
- Sexton, Patrick M.
Publication type:
Article
Structural biology: Meet the B family.
Published in:
Nature, 2013, v. 499, n. 7459, p. 417, doi. 10.1038/nature12413
By:
- Sexton, Patrick M.;
- Wootten, Denise
Publication type:
Article
Consequences of splice variation on Secretin family G protein-coupled receptor function.
Published in:
2012
By:
- Furness SG;
- Wootten D;
- Christopoulos A;
- Sexton PM;
- Furness, Sebastian G B;
- Wootten, Denise;
- Christopoulos, Arthur;
- Sexton, Patrick M
Publication type:
journal article
Consequences of splice variation on Secretin family G protein-coupled receptor function.
Published in:
British Journal of Pharmacology, 2012, v. 166, n. 1, p. 98, doi. 10.1111/j.1476-5381.2011.01571.x
By:
- Furness, Sebastian GB;
- Wootten, Denise;
- Christopoulos, Arthur;
- Sexton, Patrick M
Publication type:
Article
New Insights into the Structure and Function of Class B1 GPCRs.
Published in:
Endocrine Reviews, 2023, v. 44, n. 3, p. 492, doi. 10.1210/endrev/bnac033
By:
- Cary, Brian P;
- Zhang, Xin;
- Cao, Jianjun;
- Johnson, Rachel M;
- Piper, Sarah J;
- Gerrard, Elliot J;
- Wootten, Denise;
- Sexton, Patrick M
Publication type:
Article
Impact of secretin receptor homo-dimerization on natural ligand binding.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48853-6
By:
- Harikumar, Kaleeckal G.;
- Piper, Sarah J.;
- Christopoulos, Arthur;
- Wootten, Denise;
- Sexton, Patrick M.;
- Miller, Laurence J.
Publication type:
Article
Structure and dynamics of the active Gs-coupled human secretin receptor.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-17791-4
By:
- Dong, Maoqing;
- Deganutti, Giuseppe;
- Piper, Sarah J.;
- Liang, Yi-Lynn;
- Khoshouei, Maryam;
- Belousoff, Matthew J.;
- Harikumar, Kaleeckal G.;
- Reynolds, Christopher A.;
- Glukhova, Alisa;
- Furness, Sebastian G. B.;
- Christopoulos, Arthur;
- Danev, Radostin;
- Wootten, Denise;
- Sexton, Patrick M.;
- Miller, Laurence J.
Publication type:
Article
Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening.
Published in:
PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0174719
By:
- Coudrat, Thomas;
- Christopoulos, Arthur;
- Sexton, Patrick Michael;
- Wootten, Denise
Publication type:
Article
Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.
Published in:
PLoS Computational Biology, 2017, v. 13, n. 11, p. 1, doi. 10.1371/journal.pcbi.1005819
By:
- Coudrat, Thomas;
- Simms, John;
- Christopoulos, Arthur;
- Wootten, Denise;
- Sexton, Patrick M.
Publication type:
Article

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