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- Title
Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature.
- Authors
Sobas, Marta; Podolak-Dawidziak, Maria; Lewandowski, Krzysztof; Bator, Michał; Wróbel, Tomasz
- Abstract
This article collects several published cases in which immune thrombocytopenic purpura (ITP) is followed by essential thrombocythemia (ET) and vice versa. This surprising clinical condition is possible, but very rare and difficult to diagnose and manage. We have made an attempt to analyse the possible causes of the sequential appearance of ITP and ET taking into consideration the following: alteration of the thrombopoietin (TPO) receptor, the role of autoimmunity and inflammation, and cytokine modulation. A better understanding of these interactions may provide opportunities to determine predisposing factors and aid in finding new treatment modalities both for ITP and ET patients.
- Subjects
IDIOPATHIC thrombocytopenic purpura; THROMBOCYTOPENIA; THROMBOPOIETIN receptors; LITERATURE reviews; DIAGNOSIS; CYTOKINES
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 20, p10918
- ISSN
1661-6596
- Publication type
Case Study
- DOI
10.3390/ijms222010918