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- Title
The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition.
- Authors
Kaliszewska, Aleksandra; Allison, Joseph; Martini, Matteo; Arias, Natalia; Pifferi, Fabien; Terrien, Jérémy
- Abstract
Aging is inevitable and it is one of the major contributors to cognitive decline. However, the mechanisms underlying age-related cognitive decline are still the object of extensive research. At the biological level, it is unknown how the aging brain is subjected to progressive oxidative stress and neuroinflammation which determine, among others, mitochondrial dysfunction. The link between mitochondrial dysfunction and cognitive impairment is becoming ever more clear by the presence of significant neurological disturbances in human mitochondrial diseases. Possibly, the most important lifestyle factor determining mitochondrial functioning is nutrition. Therefore, with the present work, we review the latest findings disclosing a link between nutrition, mitochondrial functioning and cognition, and pave new ways to counteract cognitive decline in late adulthood through diet.
- Subjects
OLDER people; MITOCHONDRIA; COGNITION disorders; DIET; AGING
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 7, p3574
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22073574