We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer.
- Authors
Lee, Han Yeoung; Son, Seung Wan; Moeng, Sokviseth; Choi, Soo Young; Park, Jong Kook
- Abstract
Cancer is a global health concern, and the prognosis of patients with cancer is associated with metastasis. Multistep processes are involved in cancer metastasis. Accumulating evidence has shown that cancer cells acquire the capacity of anoikis resistance and anchorage-independent cell growth, which are critical prerequisite features of metastatic cancer cells. Multiple cellular factors and events, such as apoptosis, survival factors, cell cycle, EMT, stemness, autophagy, and integrins influence the anoikis resistance and anchorage-independent cell growth in cancer. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are dysregulated in cancer. They regulate cellular signaling pathways and events, eventually contributing to cancer aggressiveness. This review presents the role of miRNAs and lncRNAs in modulating anoikis resistance and anchorage-independent cell growth. We also discuss the feasibility of ncRNA-based therapy and the natural features of ncRNAs that need to be contemplated for more beneficial therapeutic strategies against cancer.
- Subjects
NON-coding RNA; ANOIKIS; LINCRNA; TUMOR growth; CELL cycle; INTEGRINS; AUTOPHAGY
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 2, p627
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22020627