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- Title
Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects.
- Authors
Lee, Kyung-Eun; Jeong, Sugyeong; Yun, Seok Kyun; Kyung, Seoyeon; Sophie, Abadie; Moh, Sang Hyun; Seo, Hyo Hyun; Park, Myeong Sam; Kang, Seunghyun; Yeo, Hyeonju
- Abstract
In recent years, a number of active materials have been developed to provide anti-aging benefits for skin and, among them, peptides have been considered the most promising candidate due to their remarkable and long-lasting anti-wrinkle activity. Recent studies have begun to elucidate the relationship between the secretion of emotion-related hormones and skin aging. Kisspeptin, a neuropeptide encoded by the KISS1 gene, has gained attention in reproductive endocrinology since it stimulates the reproductive axis in the hypothalamus; however, the effects of Kisspeptin on skin have not been studied yet. In this study, we synthesized Kisspeptin-10 and Kisspeptin-E, which are biologically active fragments, to mimic the action of Kisspeptin. Next, we demonstrated the anti-aging effects of the Kisspeptin-mimicking fragments using UV-induced skin aging models, such as UV-induced human dermal fibroblasts (Hs68) and human skin explants. Kisspeptin-E suppressed UV-induced 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) stimulation leading to a regulation of skin aging related genes, including type I procollagen, matrix metalloproteinases-1 (MMP-1), interleukin-6 (IL-6), and IL-8, and rescued the skin integrity. Taken together, these results suggest that Kisspeptin-E could be useful to improve UV-induced skin aging by modulating expression of stress related genes, such as 11β-HSD1.
- Subjects
SKIN aging; ENDOCRINOLOGY of human reproduction; INTERLEUKIN-6; PEPTIDES
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 22, p8439
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21228439