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- Title
Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development.
- Authors
Lin, Tao; Lee, Jae Eun; Kang, Jung Won; Shin, Hyeon Yeong; Lee, Ju Bin; Jin, Dong Il
- Abstract
Mammalian oocytes and early embryos derived from in vitro production are highly susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation embryo development, functional proteins must be folded properly in the endoplasmic reticulum (ER) to maintain oocyte and embryo development. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of ER stress and unfolded protein response (UPR) signaling pathways. ER stress and UPR signaling have been identified in mammalian oocytes and embryos produced in vitro, suggesting that modulation of ER stress and UPR signaling play very important roles in oocyte maturation and the development of preimplantation embryos. In this review, we briefly describe the current state of knowledge regarding ER stress, UPR signaling pathways, and their roles and mechanisms in mammalian (excluding human) oocyte maturation and preimplantation embryo development.
- Subjects
ENDOPLASMIC reticulum; OXIDATIVE stress; OVUM; EMBRYOS; APOPTOSIS
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 2, p409
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20020409