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- Title
Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects.
- Authors
Mayr, Judith; Bachl, Jürgen; Schlossmann, Jens; Díaz, David Díaz
- Abstract
A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells.
- Subjects
CATIONS; AMMONIUM compounds; ANTI-infective agents; ESCHERICHIA coli; BIOCOMPATIBILITY; ERYTHROCYTES; PHYSIOLOGY; THERAPEUTICS
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 2, p303
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18020303