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- Title
Exosomes as miRNA Carriers: Formation--Function--Future.
- Authors
Xiaojie Yu; Odenthal, Margarete; Fries, Jochen W. U.
- Abstract
Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes' formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.
- Subjects
EXOSOMES; NUCLEIC acids; MICRORNA; GROWTH factors; GENE expression
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 12, p2028
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17122028