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- Title
Notch Signaling in Pancreatic Development.
- Authors
Xu-Yan Li; Wen-Jun Zhai; Chun-Bo Teng
- Abstract
The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.
- Subjects
PROGENITOR cells; NOTCH genes; CELL differentiation; ISLANDS of Langerhans; FIBROBLAST growth factors
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 1, p48
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17010048