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- Title
The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis.
- Authors
Jing Wang; Hong Lu; Yingzhi Xu; Xiaofeng Hu; Wei Chen; Shang Li
- Abstract
In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
- Subjects
TOLL-like receptors; AQUEOUS humor; ENDOTOXINS; LABORATORY mice; NF-kappa B; CELLULAR signal transduction; IRIDOCYCLITIS
- Publication
International Journal of Molecular Sciences, 2012, Vol 13, Issue 2, p2110
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms13022110