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- Title
Association of neutrophil to lymphocyte ratio with bone mineral density in post-menopausal women: a systematic review and meta-analysis.
- Authors
Salimi, Maryam; Khanzadeh, Monireh; Nabipoorashrafi, Seyed Ali; Seyedi, Seyed Arsalan; Yaghoobpoor, Shirin; Brismée, Jean-Michel; Lucke-Wold, Brandon; Ebadi, Mehrnoosh; Ghaedi, Arshin; Kumar, Varun Singh; Mirghaderi, Peyman; Rabie, Hamid; Khanzadeh, Shokoufeh
- Abstract
Background: We conducted a systematic review and meta-analysis to compare the neutrophil lymphocyte ratio (NLR) levels between women with post-menopausal osteopenia or osteoporosis to those with normal bone mineral density (BMD). Methods: We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 19, 2022, only in English language. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Newcastle–Ottawa scale for quality assessment. Results: Overall, eight articles were included in the analysis. Post-menopausal women with osteoporosis had elevated levels of NLR compared to those without osteoporosis (SMD = 1.03, 95% CI = 0.18 to 1.88, p = 0.017, I2 = 98%). In addition, there was no difference between post-menopausal women with osteopenia and those without osteopenia in neutrophil lymphocyte ratio (NLR) levels (SMD = 0.58, 95% CI=-0.08 to 1.25, p = 0.085, I2 = 96.8%). However, there was no difference between post-menopausal women with osteoporosis and those with osteopenia in NLR levels (SMD = 0.75, 95% CI=-0.01 to 1.51, p = 0.05, I2 = 97.5%, random-effect model). Conclusion: The results of this study point to NLR as a potential biomarker that may be easily introduced into clinical settings to help predict and prevent post-menopausal osteoporosis.
- Subjects
NEUTROPHIL lymphocyte ratio; BONE density; POSTMENOPAUSE; OSTEOPOROSIS in women; OSTEOPENIA
- Publication
BMC Women's Health, 2024, Vol 24, Issue 1, p1
- ISSN
1472-6874
- Publication type
Article
- DOI
10.1186/s12905-024-03006-1