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- Title
Role of 1,25-Dihydroxy Vitamin D<sub>3</sub> and Parathyroid Hormone in Urinary Calcium Excretion in Calcium Stone Formers.
- Authors
Won Tae Kim; Yong-June Kim; Seok Joong Yun; Kyung-Sub Shin; Young Deuk Choi; Sang Cheol Lee; Wun-Jae Kim
- Abstract
Purpose: To find out the possible role of 1,25(OH)2 vitamin D3 [1,25(OH)2D3] and parathyroid hormone (PTH) as intrinsic factors in urinary calcium stone formers (SFs), we investigated their relationship with serum and urinary biochemical parameters. Materials and Methods: A total of 326 calcium SFs (male: 204, female: 122) were enrolled and underwent outpatient metabolic evaluations including 1,25(OH)2D3 and PTH as well as serum and 24-hour urinary biochemical parameters. As control, 163 age- and sex-matched (2:1) individuals (non-SFs) who have never urinary stone episode were included. Results: 1,25(OH)2D3 level was positively correlated with urinary calcium excretion (r=0.347, p<0.001). The hyper- calciuric group and recurrent SFs had higher serum 1,25(OH) 2D3 levels than the normocalciuric group (p<0.001) and first SFs (p=0.050). In the adjusted multiple linear regression analysis, serum 1,25(OH)2D3 level (β=0.259, p<0.001) and serum PTH level (β=-0.160, p<0.001) were significantly correlated with urinary calcium excretion. The patients in highest tertile of 1,25(OH)2D3 had a more than 3.1 fold risk of hypercalciuria than those in the lowest tertile (odds ratio=3.14, 95% confidence interval: 1.431-6.888, p=0.004). No correlation was observed be-tween PTH and 1,25(OH)2D3 (R=0.005, p=0.929) in calcium SFs, while a negative correlation was found in controls (R=-0.269, p=0.001). Conclusion: 1,25(OH)2D3 was closely correlated with urinary calcium excretion, and high 1,25(OH)2D3 levels were detected in the hypercalciuric group and in recurrent SFs. However, 1,25(OH)2D3 was not correlated with PTH in calcium SFs. These findings suggest that 1,25(OH)2D3 might be important intrinsic factor for altered calcium regulation in SFs.
- Subjects
VITAMIN D; PARATHYROID hormone; CALCIUM; URINALYSIS; BLOOD serum analysis; HYPERCALCIUREA
- Publication
Yonsei Medical Journal, 2014, Vol 55, Issue 5, p1326
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2014.55.5.1326