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- Title
Effects of Cross-linked Hyaluronic Acid in a Rat Model of Vestibular and Cochlear Toxicity.
- Authors
Erkoç, Erdal; Çetin, Aslı Çakır; Durankaya, Serpil Mungan; Mıçılı, Serap Çilaker; Keskinoğlu, Pembe; Yılmaz, Osman; Kırkım, Günay; Güneri, Enis Alpin
- Abstract
Objective: To investigate the effects of cross-linked hyaluronic acid (CLHA) in an experimental model of vestibulotoxicity and cochleotoxicity. Methods: Twenty-eight female Wistar albino rats (200-250 g) were divided into four groups. Group A received 0.06 mL of 13.33 mg/mL gentamicin, Group B received 0.06 mL of CLHA, Group C received 0.03 mL of 26.66 mg/mL gentamicin and 0.03 mL CLHA, and Group D received 0.06 mL of 0.09% saline. All groups underwent auditory brainstem response testing at 4-32 kHz, signal-to-noise ratio of distortion product otoacoustic emission measurements at 1.5-8 kHz and vestibular tests on days 0,1,7,10. The rats were sacrificed, and their labyrinths were histologically assessed and scored. Results: The hearing thresholds of Groups A and C were similar and significantly higher than those of the other groups at all frequencies, beginning from day 1. The vestibular and histological scores of Groups A and C were similar and significantly higher than those of the other groups from day 1. The audiological results, vestibular scores, and histological scores of Groups B and D were similar, except for a temporary middle ear effusion and hearing threshold shift in Group B. No significant deterioration was observed in the audiological, vestibular, and histological analyses of Groups B and D. Conclusion: That both Group A and Group C similarly showed worsening audiological, vestibular, and histological tests suggests that CLHA did not alter the pharmacokinetics and histologic results of gentamicin.
- Subjects
OTOTOXICITY; HYALURONIC acid; OTITIS media with effusion; ANIMAL disease models; OTOACOUSTIC emissions
- Publication
Turkish Archives of Otolaryngology / Türk Otolarengoloji Arsivi, 2023, Vol 61, Issue 3, p124
- ISSN
0304-4793
- Publication type
Article
- DOI
10.4274/tao.2023.2023-5-14