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- Title
Pneumatic displacement with intravitreal tPA injection versus vitrectomy with sub retinal tPA injection in small and medium sub macular hemorrhages- a multicenter comparative study.
- Authors
Barzelay, Aya; Daniels, Avishai; Cohen, Gal Yaakov; Barak, Adiel; Schwartz, Shulamit; Katz, Gabriel
- Abstract
Purpose: Comparing between the visual outcomes and post operative complications of two surgical treatments for sub macular hemorrhage, pars plana vitrectomy with tissue plasminogen activator (tPA) injection procedure, and pneumatic displacement of submacular hemorrhage with intravitreal tPA injection. Methods: A retrospective chart review of patients with sub macular hemorrhage (SMH) was performed. Data was collected from 150 patients with sub macular hemorrhage. Patients were followed up from the day of admission and up to a year post surgery. Evaluation included visual acuity, optical coherence tomography (OCT), fundus examination and rates of complications. Results: Pars plana vitrectomy procedure has showed a better visual outcome in small SMH. Comparing complications between the two treatment modalities, no significant difference has been found in the study. Conclusions: Pars plana vitrectomy and tPA showed a clear advantage with a trend of better visual acuity as well as a significant predictor to better visual acuity for small and medium sub macular hemorrhage. Why carry out this study?: • Either Pneumatic Displacement and tPA injection, or Pars Plana Vitrectomy with subretinal tPA injection were shown to be effective in hemo displacement. • There is no consensus among the therapists regarding preferred treatment options for subretinal bleeding. What was learned from the study?: • PPV + tPA exhibited a clear advantage with a trend of better BCVA at all time points as well as a significant predictor to better BCVA for small and medium SMH. • Comparing complications between the two treatment modalities, we did not find a significant difference. Implying to equal safety to both surgeries.
- Subjects
VITRECTOMY; INTRAVITREAL injections; TISSUE plasminogen activator; PARS plana; OPTICAL coherence tomography; INJECTIONS
- Publication
BMC Ophthalmology, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2415
- Publication type
Article
- DOI
10.1186/s12886-024-03468-9