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- Title
The Association Between Physical Activity With Cognitive Function and Brain-Derived Neurotrophic Factor in People With Parkinson's Disease: A Pilot Study.
- Authors
Khalil, Hanan; Alomari, Mahmoud A.; Khabour, Omar; Al-Hieshan, Aya; Bajwa, Jawad A.
- Abstract
The objective of this study was to examine the effect of physical capacity on the relationship of brain-derived neurotrophic factor (BDNF) with cognitive function in people with PD. For this study, serum BDNF levels were measured in 29 PD participants and 30 healthy controls. Cognitive function was assessed using the Montreal Cognitive Assessment (MOCA) scale. Physical capacity was evaluated using the 6-min walk distance (6-MWD). Participants were categorized into low or high physical capacity group according to their 50th percentile 6-MWD. It was found that MOCA total score correlated with serum BDNF level (r = .44, P = .012) in the entire PD sample. This correlation remained significant only in the low physical capacity group (r = .62; P = .03) but not in the high physical capacity group (r = .31; P = .22). It was concluded that the relationship of BDNF with cognitive function might be dependent on physical capacity. The results are preliminary, thus future studies are needed to confirm these findings.
- Subjects
COGNITION; EXERCISE tests; PARKINSON'S disease; PROBABILITY theory; PILOT projects; PHYSICAL activity; BRAIN-derived neurotrophic factor; BLOOD
- Publication
Journal of Aging & Physical Activity, 2017, Vol 25, Issue 4, p646
- ISSN
1063-8652
- Publication type
Article
- DOI
10.1123/japa.2016-0121