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- Title
Curcumin: A natural antiinflammatory agent.
- Authors
Kohli, K.; Ali, J.; Ansari, M. J.; Raheman, Z.
- Abstract
Extensive scientific research on curcumin, a natural compound present in the rhizomes of plant Curcuma longa Linn., demonstrated its antiinflammatory action. Curcumin was found to inhibit arachidonic acid metabolism, cyclooxygenase, lipoxygenase, cytokines (Interleukins and tumour necrosis factor) Nuclear factor-κB and release of steroidal hormones. Curcumin was reported to stabilize lysosomal membrane and cause uncoupling of oxidative phosphorylation besides having strong oxygen radical scavenging activity, which was responsible for its antiinflammatory property. In various animal studies, a dose range of 100-200 mg/kg body weight exhibited good anti-inflammatory activity and seemed to have negligible adverse effect on human systems. Oral LD50 in mice was found to be more than 2.0 g/kg body weight.
- Subjects
TURMERIC; ANTI-inflammatory agents; ARACHIDONIC acid; CYCLOOXYGENASES; NF-kappa B; CYTOKINES
- Publication
Indian Journal of Pharmacology, 2005, Vol 37, Issue 3, p141
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/0253-7613.16209