We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Strain identity of Bordetella pertussis isolates from household members based on whole‐genome sequencing.
- Authors
Kamachi, Kazunari; Koide, Kentaro; Otsuka, Nao; Goto, Masataka; Kenri, Tsuyoshi
- Abstract
We evaluated the genetic diversity of Bordetella pertussis, the causative agent of pertussis, within households by whole‐genome sequencing. In pairwise comparisons of 23 isolates collected from 11 households, single‐nucleotide polymorphism (SNP) analysis revealed extremely low SNP diversity (≤1 SNP) between isolate pairs: no SNPs were detected in 10 households and one SNP was obtained in the remaining household. This SNP was uncommon for B. pertussis and resulted in a nonsynonymous substitution (Ala303Thr) in nicotinate phosphoribosyltransferase. We demonstrated that the same strain is transmitted between household members and that B. pertussis is genomically stable during household transmission.
- Subjects
WHOLE genome sequencing; BORDETELLA pertussis; HOUSEHOLDS; SINGLE nucleotide polymorphisms; GENETIC variation; COMPARATIVE genomics; NUCLEOTIDE sequencing
- Publication
Microbiology & Immunology, 2024, Vol 68, Issue 3, p111
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/1348-0421.13113