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- Title
Comparing 3 mm and 5 mm laparoscopic liver biopsy samples in dogs.
- Authors
Larose, Philippe Chagnon; Brisson, Brigitte A.; Foster, Robert A.; Monteith, Gabrielle
- Abstract
Objective: To determine whether 3 mm cup biopsy forceps (CBF) provide equivalent diagnostic samples to 5 mm CBF for histopathologic diagnosis, bacterial culture, and copper quantification. Study design: Clinical prospective study. Animals: Ten client‐owned dogs, presenting for laparoscopic liver biopsy (LLB). Methods: Dogs underwent LLB, and paired samples were collected using 3 and 5 mm CBF. Portal triad and hepatic lobule counts, crush and fragmentation artifacts, copper concentration, bacterial culture results, and agreement on histopathologic diagnosis were compared. Results: Both CBF sizes allowed for easy sample collection and resulted in minimal hemorrhage. An average of 12.13 (confidence limit (CL): 9.4–14.9) and 17.84 (CL: 15.1–20.6) portal triads were obtained using a 3 and 5 mm CBF, respectively (p =.0003). A portal triad count of 11 or more was achieved in 73.3% of the 3 mm and 93.3% of the 5 mm samples. Gwets AC1 coefficient showed a high level of agreement (0.8) for overall histopathologic diagnosis (p <.0001). The 3 mm CBF crush scores were higher (median of the differences: −1; range: −1 to 1) (p =.035). There was no difference in fragmentation scores (p =.935). Conclusion: The 3 mm CBF yielded smaller samples in terms of size and portal triad count compared with the 5 mm CBF. However, the portal triad count was sufficient in a majority of samples and histologic agreement with the 5 mm CBF was excellent. Clinical significance: In dogs, a 3 mm CBF yields adequate samples for histopathologic interpretation, copper quantification, and bacterial culture.
- Subjects
LIVER biopsy; DOGS; BACTERIAL cultures; CONFIDENCE intervals; COPPER
- Publication
Veterinary Surgery, 2024, Vol 53, Issue 4, p742
- ISSN
0161-3499
- Publication type
Article
- DOI
10.1111/vsu.14006