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- Title
Dearomatization of Indoles via a Phenol-Directed Vanadium- Catalyzed Asymmetric Epoxidation and Ring-Opening Cascade.
- Authors
Han, Long; Zhang, Wei; Shi, Xiao ‐ Xin; You, Shu ‐ Li
- Abstract
An enantioselective dearomatization of indole derivatives was realized by the complexes derived from the vanadium complex VO(acac)2 and C2-symmetric bis-hydroxamic acid (BHA) ligands. The reaction proceeded via asymmetric epoxidation and ring-opening by the linked phenol cascade, affording 5a,6,10b,11-tetrahydrochromeno[2,3- b]indol-10b-ol derivatives in up to 83% yield and 98% ee under mild reaction conditions.
- Subjects
AROMATIZATION; INDOLE compounds; VANADIUM; ENANTIOSELECTIVE catalysis; EPOXIDATION; HYDROXAMIC acids
- Publication
Advanced Synthesis & Catalysis, 2015, Vol 357, Issue 14/15, p3064
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500557