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- Title
Oxidative Aminocarbonylation of Terminal Alkynes for the Synthesis of Alk-2-ynamides by Using Palladium-on-Carbon as Efficient, Heterogeneous, Phosphine-Free, and Reusable Catalyst.
- Authors
Gadge, Sandip T.; Khedkar, Mayur V.; Lanke, Satish R.; Bhanage, Bhalchandra M.
- Abstract
Palladium-on-carbon (Pd/C)-catalyzed oxidative aminocarbonylations of alk-1-ynes with secondary amines provide the corresponding alk-2-ynamides in a good to excellent yields. This new methodology is applicable for the synthesis of a wide range of biologically active alk-2-ynamide derivatives. The developed protocol avoids the use of phosphine ligands, with an additional advantage of palladium catalyst recovery and reuse for up to four consecutive cycles.
- Publication
Advanced Synthesis & Catalysis, 2012, Vol 354, Issue 10, p2049
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201200041