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- Title
Human whole blood T<sub>2</sub> relaxometry at 3 Tesla.
- Authors
Chen, Jean J.; Pike, G. Bruce
- Abstract
A precise understanding of human blood spin-spin relaxation is of major importance for numerous applications, particularly functional magnetic resonance imaging (fMRI), which is increasingly performed at 3 Tesla. It is well known that T2 measured from partially deoxygenated blood depends on the Carr-Purcell Meiboom-Gill (CPMG) refocusing interval (τ180) and on blood oxygenation ( Y), yet debate remains over the quantification of this phenomenon, primarily with respect to the accuracy of its characterization by the diffusion and fast two-site exchange models. In this study, a detailed characterization of the deoxygenation-induced T2 reduction in human whole blood, as well as a comprehensive assessment of the role of τ180, were performed at 3 T. The diffusion model was found to better fit the observed T2 behavior as compared with the exchange model. The estimated diffusion-model parameters suggest the T2 decay enhancement at 3 T is due to a linear increase in the magnitude of deoxygenation-induced field inhomogeneities with field strength. These findings also confirm the potential of τ180 manipulation in measuring changes in venous blood volume. Magn Reson Med 61:249-254, 2009. © 2009 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2009, Vol 61, Issue 2, p249
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21858