We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging.
- Authors
Neubauer, Anne M.; Sim, Hoon; Winter, Patrick M.; Caruthers, Shelton D.; Williams, Todd A.; Robertson, J. David; Sept, David; Lanza, Gregory M.; Wickline, Samuel A.
- Abstract
Contrast agents targeted to molecular markers of disease are currently being developed with the goal of identifying disease early and evaluating treatment effectiveness using noninvasive imaging modalities such as MRI. Pharmacokinetic profiling of the binding of targeted contrast agents, while theoretically possible with MRI, has thus far only been demonstrated with more sensitive imaging techniques. Paramagnetic liquid perfluorocarbon nanoparticles were formulated to target αvβ3-integrins associated with early atherosclerosis in cholesterol-fed rabbits to produce a measurable signal increase on magnetic resonance images after binding. In this work, we combine quantitative information of the in vivo binding of this agent over time obtained by means of MRI with blood sampling to derive pharmacokinetic parameters using simultaneous and individual fitting of the data to a three compartment model. A doubling of tissue exposure (or area under the curve) is obtained with targeted as compared to control nanoparticles, and key parameter differences are discovered that may aid in development of models for targeted drug delivery. Magn Reson Med 60:1353-1361, 2008. © 2008 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2008, Vol 60, Issue 6, p1353
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21795