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- Title
Sinapic acid safeguards cardiac mitochondria from damage in isoproterenol‐induced myocardial infarcted rats.
- Authors
Stanely Mainzen Prince, P.; Dey, Pinaki; Roy, S. J.
- Abstract
Myocardial infarction (MI) is a life‐threatening disease. In this study, we examined the anti‐mitochondrial damaging effects of sinapic acid (SA) in isoproterenol (ISO)‐induced myocardial infarcted rats. Myocardial infarcted rats were prepared by injecting ISO (100 mg/kg body weight) on the 9th and 10th day. Rats were pretreated and cotreated with SA (12 mg/kg body weight) orally, daily for 10 days. A considerable increase in serum lactate dehydrogenase, creatine kinase, myoglobin, and cardiac troponin‐T was noticed in the ISO‐induced rats. ISO also significantly amplified lipid peroxidation and calcium ions, and depleted the antioxidant system and mitochondrial enzymes in rat's heart mitochondria. SA treatment improved the distorted above‐ mentioned biochemical parameters in ISO‐treated rats with its anti‐mitochondrial damaging effects. This ultrastructural study on heart mitochondria and in vitro studies also confirmed the effects of SA. The current findings are suggestive of SA's cardioprotective effects.
- Subjects
INTERNATIONAL Organization for Standardization; MITOCHONDRIA; RATS; CREATINE kinase; CALCIUM ions; LACTATE dehydrogenase; SALICYLIC acid
- Publication
Journal of Biochemical & Molecular Toxicology, 2020, Vol 34, Issue 10, p1
- ISSN
1095-6670
- Publication type
Article
- DOI
10.1002/jbt.22556