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- Title
Preparation and Conformational Properties of Benzylpenicilloyl-oligo- L-lysine Conjugates.
- Authors
Rolli, Hanspeter; Lüscher, Immanuel F.; Schneider, Conrad H.; Toniolo, Claudio; Bonora, Gian Maria
- Abstract
Selected oligo- L-lysine carriers and a poly- L-lysine were penicilloylated with benzylpenicillin. The resulting conjugates 2- 6 were studied by IR. absorption in the solid state and circular dichroism measurements in solution. The IR. data demonstrate the lack of β-structure formation even in medium-sized peptides where such structures might be expected on the basis of previous studies on differently substituted oligo- L-lysines. Considerable proportions of right-handed α -helical conformation are exhibited by the icosa- L-lysine and poly- L-lysine conjugates 5 and 6 in water and 2,2,2-trifluoroethanol. Difficulties in obtaining fully penicilloylated conjugates are not related to the extent of α-helical conformation in aqueous solution.
- Publication
Helvetica Chimica Acta, 1982, Vol 65, Issue 7, p1965
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19820650703