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- Title
Astigmatism and optical coherence tomography measurements.
- Authors
Hwang, Young; Lee, Sang; Kim, Yong; Lee, Jong; Yoo, Chungkwon
- Abstract
Background: To evaluate the effect of astigmatism change on measurement of retinal nerve fiber layer (RNFL) and macular thickness by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT; Carl Zeiss Meditec, Dublin, CA, USA). Methods: A total of 30 right eyes from 30 healthy young subjects underwent RNFL and macular thickness measurements using Cirrus HD OCT. Measurements were performed at the baseline state and induced with-the-rule (WTR) and against-the-rule (ATR) astigmatism states by wearing toric soft contact lenses (+1.50 −3.25 diopter × 90° and +1.50 −3.25 diopter × 180° respectively). Dfferences in RNFL and macular thickness between the baseline state and induced astigmatism states were analyzed. Results: Wearing toric soft contact lenses induced a mean 2.92 diopter WTR and 3.18 diopter ATR astigmatism respectively. After signal strength change adjustment, RNFL thicknesses of average, superior quadrant, 12 and 6 o'clock hour sectors decreased after induction of a WTR astigmatism (mean difference range, 1.58 to 6.88 μm); RNFL thicknesses of average, nasal, temporal quadrants, 2, 3, and 9 o'clock hour sectors decreased after induction of an ATR astigmatism (mean difference range, 0.75 to 5.11 μm) (all P values <0.05). Macular thickness was not significantly affected by astigmatism changes (all P values ≥ 0.250). Conclusion: Although the amount of change was not substantial, RNFL thickness measured by Cirrus HD OCT was affected by astigmatism changes induced by contact lenses. It may be warranted to consider the effect of astigmatism on RNFL thickness measured by OCT in eyes with higher degrees of astigmatism.
- Subjects
ASTIGMATISM; OPTICAL coherence tomography; PHARMACODYNAMICS; NERVE fibers; THICKNESS measurement; CONTACT lenses; GLAUCOMA diagnosis
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2012, Vol 250, Issue 2, p247
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-011-1788-4