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- Title
Rapid-CNS<sup>2</sup>: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study.
- Authors
Patel, Areeba; Dogan, Helin; Payne, Alexander; Krause, Elena; Sievers, Philipp; Schoebe, Natalie; Schrimpf, Daniel; Blume, Christina; Stichel, Damian; Holmes, Nadine; Euskirchen, Philipp; Hench, Jürgen; Frank, Stephan; Rosenstiel-Goidts, Violaine; Ratliff, Miriam; Etminan, Nima; Unterberg, Andreas; Dieterich, Christoph; Herold-Mende, Christel; Pfister, Stefan M.
- Abstract
The glioma samples run with the Rapid CNS A panel as target region were each loaded onto FLO-MIN106 R9.4.1 flow cells and sequencing was controlled in real-time by ReadFish (using a GPU powered consumer notebook). "PANEL A" indicates samples sequenced using Rapid CNS A, and "PANEL B" indicates samples sequenced using Rapid CNS B (sample by Rapid-CNS2 and 850 k identified as AT/RT excluded, depicted in Supplementary Fig. One sample identified as a glioma by histology was correctly classified as an atypical teratoid/rhabdoid tumor by Rapid-CNS SP 2 sp (confirmed by EPIC array analysis, Supplementary Fig.
- Subjects
NERVOUS system tumors
- Publication
Acta Neuropathologica, 2022, Vol 143, Issue 5, p609
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-022-02415-6