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- Title
Amyotrophic lateral sclerosis is over-represented in two Huntington's disease brain bank cohorts: further evidence to support genetic pleiotropy of pathogenic HTT gene expansion.
- Authors
Hickman, Richard A.; Dewan, Ramita; Cortes, Etty; Traynor, Bryan J.; Marder, Karen; Vonsattel, Jean-Paul
- Abstract
Among 751 brains, 6 (0.8%) were diagnosed pathologically as HD and ALS (HD/ALS), exceeding the United States prevalence of ALS (0.0052%, I P i < 0.0001, Fisher's exact test) [[5]]. Recent data have expanded the phenotypic spectrum of Huntington's disease (HD) and the effects of pathogenic I HTT i repeat expansions on the human brain.
- Subjects
HUNTINGTON disease; GENETIC pleiotropy; MOTOR neuron diseases; BRAIN diseases; BRAIN banks; AMYOTROPHIC lateral sclerosis; EFFERENT pathways
- Publication
Acta Neuropathologica, 2022, Vol 143, Issue 1, p105
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-021-02385-1