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- Title
Development of super nanoantimicrobials combining AgCl, tetracycline and benzalkonium chloride.
- Authors
Hossain, Syed Imdadul; Bajrami, Diellza; Altun, Nazan; Izzi, Margherita; Calvano, Cosima Damiana; Sportelli, Maria Chiara; Gentile, Luigi; Picca, Rosaria Anna; Gonzalez, Pelayo; Mizaikoff, Boris; Cioffi, Nicola
- Abstract
In this work, we demonstrate that a simple argentometric titration is a scalable, fast, green and robust approach for producing AgCl/antibiotic hybrid antimicrobial materials. We titrated AgNO3 into tetracycline hydrochloride (TCH) aqueous solution, thus forming AgCl/TCH in a one-step procedure. Furthermore, we investigated the one-pot synthesis of triply synergistic super-nanoantimicrobials, combining an inorganic source of Ag+ ions (AgCl), a disinfecting agent (benzyl-dimethyl-hexadecyl-ammonium chloride, BAC) and a molecular antibiotic (tetracycline hydrochloride, TCH). Conventional antimicrobial tests, industrial biofilm detection protocols, and in situ IR-ATR microbial biofilm monitoring, have been adapted to understand the performance of the synthesized super-nanoantimicrobial. The resulting hybrid AgCl/BAC/TCH nanoantimicrobials are found to be synergistically active in eradicating Salmonella enterica and Lentilactobacillus parabuchneri bacteria and biofilms. This study paves the way for the development of a new class of super-efficient nanoantimicrobials that combine relatively low amounts of multiple active species into a single (nano)formulation, thus preventing the development of antimicrobial resistance towards a single active principle.
- Subjects
BENZALKONIUM chloride; TETRACYCLINES; TETRACYCLINE; SALMONELLA enterica; ION sources
- Publication
Discover Nano, 2024, Vol 19, Issue 1, p1
- ISSN
2731-9229
- Publication type
Article
- DOI
10.1186/s11671-024-04043-3