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- Title
Possible therapeutic target MKK3 in blister formation in pemphigus.
- Authors
Kim, Rosa; Kim, Eun Hye; Ahn, Min Jeong; Choi, You Won; Choi, Hae Young; Kim, Seong Hwan; Byun, Ji Yeon
- Abstract
This article discusses the potential therapeutic target MKK3 in blister formation in pemphigus, a condition characterized by autoantibody-mediated disruption of keratinocyte adhesion. The study aims to understand the roles of MKK3 and MKK6 in pemphigus and evaluate their inhibition as a treatment approach. Immunohistochemical analysis of skin specimens from pemphigus patients showed pronounced expression of phosphorylated MKK3 and p38 MAPK, indicating their involvement in pemphigus pathogenesis. In vitro studies using an MKK3 inhibitor demonstrated improved cell-cell adhesion and reduced blister formation. Targeting MKK3 may offer a promising alternative treatment option for pemphigus and other autoimmune and inflammatory conditions.
- Subjects
PEMPHIGUS; DESMOGLEINS; MITOGEN-activated protein kinase kinase; EPIDERMAL growth factor receptors
- Publication
Archives of Dermatological Research, 2024, Vol 316, Issue 7, p1
- ISSN
0340-3696
- Publication type
Article
- DOI
10.1007/s00403-024-03136-4