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- Title
Effect of Imidafenacin on Nocturia and Sleep Disorder in Patients with Overactive Bladder.
- Authors
Wada, Naoki; Watanabe, Masaki; Kita, Masafumi; Matsumoto, Seiji; Osanai, Hiroaki; Yamaguchi, Satoshi; Numata, Atsushi; Fujisawa, Makoto; Saga, Yuji; Hou, Kyokushin; Luchi, Hiromitsu; Niiborie, Daisuke; Kura, Tatsuhiko; Taniguchi, Akihisa; Kunieda, Manabu; Nakata, Yasunobu; Kakizaki, Hidehiro
- Abstract
Objective: To evaluate the efficacy of imidafenacin on noc-turia and sleep disorder in patients with overactive bladder (OAB). Patients and Methods: A prospective multicenter study of imidafenacin 0.1 mg twice daily for patients with OAB and nocturia was conducted. At baseline and at week 4 and 8, patients were assessed using the overactive bladder symptom score (OABSS), frequency volume charts (FVC) and the Pittsburgh Sleep Quality Index (PSQI). Results: Treat-ment with imidafenacin significantly improved OAB symp-toms. Imidafenacin also improved PSQI, especially subjec-tive sleep quality, sleep latency and daytime dysfunction. In FVC, the number of daytime voids and nighttime voids sig-nificantly decreased and average voided volume significant-ly increased after imidafenacin. Subanalysis of FVC based on the patients' age revealed that nocturnal polyuria was more often found in patients aged 75 years or over than in those aged under 75 years (79 vs. 55%, p < 0.05). Treatment with imidafenacin significantly reduced the nocturnal polyuria index only in patients aged 75 years or over. Conclusions: Imidafenacin can improve nocturia and sleep disorder in pa-tients with OAB. The efficacy of imidafenacin on nocturia is attributable to an increase in bladder capacity and a de-crease in nocturnal urine volume. We conclude that imida-fenacin is an effective and safe drug for nocturia in patients With OAB.
- Subjects
SLEEP disorders treatment; ANTISPASMODICS; OVERACTIVE bladder; DRUG efficacy; POLYURIA; MEDICAL statistics
- Publication
Urologia Internationalis, 2012, Vol 89, Issue 2, p215
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000339750