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- Title
Flow-Cytometric Measurement of Cellular Changes in Urine: A Simple and Rapid Method for Perioperatively Monitoring Patients after Kidney Transplantation.
- Authors
Yu, Dah-Shyong; Sun, Guang-Huan; Lee, Shang-Sen; Wu, Ching-Jiunn; Ma, Chen-Ping; Chang, Sun-Yran
- Abstract
Objective: In renal transplant patients having graft dysfunction, it is usually difficult to obtain the accurate diagnosis, such as acute rejection, acute tubular necrosis, infection, or ciclosporin nephrotoxicity. An accurate diagnosis can provide the proper treatment of these patients, thereby lessening the chance of kidney loss. Methods: A total of 42 patients were enrolled. By using the flow-cytometric technique, the white cell populations of urine in these patients were analyzed and linked to their clinical course. All patients underwent sonography-guided biopsy of the transplanted kidney with a definitive diagnosis. Results: When 10% lymphocytes and 15% granulocytes in urine were set as the cutoff point of a normal ratio threshold, the flow-cytometric analysis presented the highest sensitivity and the highest negative predictive rate for acute tubular necrosis. However, a lower sensitivity and positive predictive rate was found in acute rejection cases. Conclusions: Our results suggest that flow-cytometric analysis of the urinary cell population can be used as an adjunct in patient follow-up after kidney transplantation.
- Subjects
KIDNEY transplantation; FLOW cytometry; TRANSPLANTATION of organs, tissues, etc.; GRAFT rejection; PATIENT monitoring
- Publication
Urologia Internationalis, 1999, Vol 62, Issue 3, p143
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000030378