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- Title
Methyl (5-(2-Thienylcarbonyl)-1H-Benzimidazole-2-yl) Carbamate, (R17934), A Synthetic Microtubule Inhibitor, Prevents Malignant Invasion In Vitro.
- Authors
Mareel, M.; de Brabander, M.
- Abstract
The effect on malignant invasion of methyl (5-(2-thienyl-carbonyl)-1H-benzimidazole-2-yl) carbamate, (R17934), a microtubule inhibitor, was examined in organotypical co-cultures of mouse sarcoma virus transformed cells (MO4) and embryonic chick tissues. In contrast with control cultures, 1 microgram/ml R17934 prevented invasion of MO4 cells into the host tissues. Since mitostatic doses of 5-fluorouracil did not inhibit invasion, we presumed that the anti-invasive properties of R17934 were correlated with a loss of microtubule mediated directional cell migration. Copyright © 1978 S. Karger AG, Basel
- Publication
Oncology, 1978, Vol 35, Issue 1, p5
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225246