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- Title
Elevated Second-Trimester Free β-hCG as an Isolated Finding and Pregnancy Outcomes.
- Authors
Brajenović-Milic, Bojana; Tišlarić, Dubravka; żuvić-Butorac, Marta; Bačiၽ, Josip; Petroviၽ, Oleg; Ristiၽ, Smiljana; Mimica, Marko; Kapoviၽ, Miljenko
- Abstract
Objective: To investigate the relationship between unexplained elevated second-trimester free β-human chorionic gonadotropin (β-hCG) levels and pregnancy complications as well as adverse pregnancy outcomes. Methods: The study cohort comprised 2,110 non-smoking women with chromosomal and structurally normal fetuses at low-risk for both Down's syndrome (risk <1:250) and neural tube defects (maternal serum α-fetoprotein <2.0 MoM). A free β-hCG value of ≥2.0 MoM was used to define the populations with elevated levels of free β-hCG. Descriptive statistics, χ² test, Fisher's exact test, and logistic regression analysis were used for statistical analysis, and p < 0.05 was considered statistically significant. Results: The mean maternal age of the study group was significantly lower than in controls (27.9 B 4.3 and 30.6 ± 5.1 years, respectively, p ± 0.05), while the proportion of primigravidas was significantly higher compared to that of controls (p < 0.05). After adjustment of the 2 groups according to maternal age and parity, we observed an increased incidence of preeclampsia among women with elevated free β-hCG levels in relation to controls (p < 0.05). However, a logistic regression analysis demonstrated that the free β-hCG level was not a predictor of the occurrence of preeclampsia. No significant relationship was found with the incidence of gestational diabetes, oligohydramnios, polyhydramnios, pregnancy-related hypertension, intrauterine growth retardation, preterm delivery, spontaneous abortion and stillbirths (p > 0.05).
- Subjects
GONADOTROPIN; SECOND trimester of pregnancy; PREGNANCY complications; NEURAL tube defects; WOMEN'S health
- Publication
Fetal Diagnosis & Therapy, 2004, Vol 19, Issue 6, p483
- ISSN
1015-3837
- Publication type
Article
- DOI
10.1159/000080159