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- Title
The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis.
- Authors
Roca-Fernández, A; Camera, V; Loncarevic-Whitaker, G; Messina, S; Mariano, R; Vincent, A; Sharma, S; Leite, MI; Palace, J
- Abstract
Myelin oligodendrocyte-antibody-associated disease (MOGAD) often presents with severe optic neuritis (ON) but tends to recover better than in aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD). We measured OCT and VEP in MOGAD and AQP4-NMOSD eyes with good visual function, with or without previous ON episodes. Surprisingly, OCT and/or VEPs were abnormal in 84% MOGAD-ON versus 38% AQP4-NMOSD-ON eyes (p = 0.009) with good vision, compared with 18% and 17% respectively of eyes with no previous ON. A sub-group with macular OCT performed as part of a research study confirmed both retinal and macular defects in visually-recovered MOGAD eyes. These findings have implications for investigation and management of MOGAD patients.
- Subjects
OPTIC neuritis; NEUROMYELITIS optica; VISUAL acuity; VISION; MYELIN oligodendrocyte glycoprotein
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2021, Vol 7, Issue 4, p1
- ISSN
2055-2173
- Publication type
Article
- DOI
10.1177/20552173211066446