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- Title
Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis.
- Authors
Fournier, Antoine Philippe; Baudron, Erwan; Wagnon, Isabelle; Aubert, Philippe; Vivien, Denis; Neunlist, Michel; Bardou, Isabelle; Docagne, Fabian
- Abstract
Background: Clinical observations support the hypothesis that stressful events increase relapse occurrence in multiple sclerosis patients, while stress-reduction strategies can modulate this effect. However, a direct cause-effect relationship between stress level and relapse cannot be firmly established from these data. Objectives: The purpose of this work was to address whether modulation of stress could interfere with symptom relapse in an animal model of multiple sclerosis with relapsing-remitting course. Methods: Mice bred in standard or enriched environment were subjected to repeated acute stress during the remission phase of relapsing-remitting PLP-induced experimental autoimmune encephalomyelitis. Results: We report that repeated acute stress induced a twofold increase in relapse incidence in experimental autoimmune encephalomyelitis. On the other hand, environmental enrichment reduced relapse incidence and severity, and reversed the effects of repeated acute stress. Conclusion: These data provide the platform for further studies on the biological processes that link stress and multiple sclerosis relapses in a suitable animal model.
- Subjects
MULTIPLE sclerosis; LIFE change events; SYMPTOMS; ENCEPHALOMYELITIS; PSYCHOLOGICAL stress
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2020, p1
- ISSN
2055-2173
- Publication type
Article
- DOI
10.1177/2055217320959806