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- Title
Dynamic Microtubules Lead the Way for Spindle Positioning.
- Authors
Pearson, Chad G.; Bloom, Kerry
- Abstract
Coordination between the asymmetric partitioning of cell-fate determinants and equal partitioning of genetic material is crucial to the generation of diverse cell types in a developing organism, and to the maintenance of genomic integrity. The emerging model is of a highly organized and dynamic cellular landscape, the form of which is defined by polarized signals within the cell. Cytoskeletal elements are necessary to generate this landscape and to provide motive forces for proper spindle positioning. These forces are generated by interactions between microtubules and the cell cortex.
- Subjects
MICROTUBULES; SPINDLE apparatus; ORGANELLES; CELL determination; ORGANISMS
- Publication
Nature Reviews Molecular Cell Biology, 2004, Vol 5, Issue 6, p481
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1402